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Prevalence of PCR Detectable Malaria Infection among Febrile Patients with a Negative Plasmodium falciparum Specific Rapid Diagnostic Test in Zanzibar.

Baltzell, K. A., Shakely, D., Hsiang, M., Kemere, J., Ali, A. S., Björkman, A., Mårtensson, A., Omar, R., Elfving, K., Msellem, M., Aydin-Schmidt, B., Rosenthal, P. J. and Greenhouse, B. (2012) Prevalence of PCR Detectable Malaria Infection among Febrile Patients with a Negative Plasmodium falciparum Specific Rapid Diagnostic Test in Zanzibar. The American journal of tropical medicine and hygiene. ISSN 1476-1645

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Abstract

We screened for malaria in 594 blood samples from febrile patients who tested negative by a Plasmodium falciparum-specific histidine-rich protein-2-based rapid diagnostic test at 12 health facilities in Zanzibar districts North A and Micheweni, from May to August 2010. Screening was with microscopy, polymerase chain reaction (PCR) targeting the cytochrome b gene (cytbPCR) of the four major human malaria species, and quantitative PCR (qPCR). The prevalence of cytbPCR-detectable malaria infection was 2% (12 of 594), including 8 P. falciparum, 3 Plasmodium malariae, and 1 Plasmodium vivax infections. Microscopy identified 4 of 8 P. falciparum infections. Parasite density as estimated by microscopy or qPCR was > 4,000 parasites/μL in 5 of 8 cytbPCR-detectable P. falciparum infections. The infections that were missed by the rapid diagnostic test represent a particular challenge in malaria elimination settings and highlight the need for more sensitive point-of-care diagnostic tools to improve case detection of all human malaria species in febrile patients.

Item Type: Article
Keywords: Malaria Infection;Febrile Patients;Plasmodium falciparum; Zanzibar
Subjects: Malaria > Diagnosis & treatment
Divisions: Other
Related URLs:
Depositing User: Mr Joseph Madata
Date Deposited: 15 Jan 2013 08:17
Last Modified: 15 Jan 2013 08:17
URI: http://ihi.eprints.org/id/eprint/1030

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