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Community effectiveness of intermittent preventive treatment for infants (IPTi) in rural southern Tanzania.

Armstrong Schellenberg, J. R. M., Shirima, K., Maokola, W., Manzi, F., Mrisho, M., Mushi, A., Mshinda, H., Alonso, P., Tanner, M. and Schellenberg, D. M. (2010) Community effectiveness of intermittent preventive treatment for infants (IPTi) in rural southern Tanzania. The American journal of tropical medicine and hygiene, 82 (5). pp. 772-81. ISSN 1476-1645

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Abstract

Intermittent preventive treatment of malaria in infants (IPTi) with sulphadoxine-pyrimethamine shows evidence of efficacy in individually randomized, controlled trials. In a large-scale effectiveness study, IPTi was introduced in April 2005 by existing health staff through routine contacts in 12 randomly selected divisions out of 24 in 6 districts of rural southern Tanzania. Coverage and effects on malaria and anemia were estimated through a representative survey in 2006 with 600 children aged 2-11 months. Coverage of IPTi was 47-76% depending on the definition. Using an intention to treat analysis, parasitemia prevalence was 31% in intervention and 38% in comparison areas (P = 0.06). In a "per protocol" analysis of children who had recently received IPTi, parasite prevalence was 22%, 19 percentage points lower than comparison children (P = 0.01). IPTi can be implemented on a large scale by existing health service staff, with a measurable population effect on malaria, within 1 year of launch.

Item Type: Article
Keywords: intermittent preventive treatment, IPTi, Tanzania, sulphadoxine-pyrimethamine,
Subjects: Malaria > Diagnosis & treatment
Divisions: Ifakara Health Institute > Biomedical
Depositing User: Mr Joseph Madata
Date Deposited: 17 Sep 2012 08:47
Last Modified: 17 Sep 2012 08:47
URI: http://ihi.eprints.org/id/eprint/106

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