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Anticonvulsant Activity of Diospyros Fischeri Root Extracts.

Moshi, M. J., Mbwambo, Z. H., Nondo, R. S. O., Masimba, P. J., Kapingu, M. C. and Magelewanya, E. S. (2006) Anticonvulsant Activity of Diospyros Fischeri Root Extracts. African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines, 4 (2). pp. 226-230. ISSN 0189-6016

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Abstract

Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the gamma-aminobutyric acid type A (GABAa) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC(50) values between 45.4 and 95.4 microg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature.

Item Type: Article
Keywords: Diospyros fischeri, Pentylenetetrazole, Anticonvulsant activity, Brine Shrimp Toxicity
Subjects: Health Systems > Surveillance, monitoring & evaluation
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 02 Apr 2013 06:46
Last Modified: 02 Apr 2013 06:46
URI: http://ihi.eprints.org/id/eprint/1258

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