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Brine Shrimp Toxicity Evaluation of Some Tanzanian Plants Used Traditionally for the Treatment of Fungal Infections.

Moshi, M. J., van den Beukel, C. J. P., Hamza, O. J. M., Mbwambo, Z. H., Nondo, R. O. S., Masimba, P. J., Matee, M. I. N., Kapingu, M. C., Mikx, F., Verweij, P. E. and van der Ven, A. J. A. M. (2006) Brine Shrimp Toxicity Evaluation of Some Tanzanian Plants Used Traditionally for the Treatment of Fungal Infections. African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines, 4 (2). pp. 219-225. ISSN 0189-6016

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Abstract

Plants which are used by traditional healers in Tanzania have been evaluated to obtain preliminary data of their toxicity using the brine shrimps test. The results indicate that 9 out of 44 plant species whose extracts were tested exhibited high toxicity with LC(50) values below 20 microg/ml. These include Aloe lateritia Engl. (Aloaceae) [19.1 microg/ml], Cassia abbreviata Oliv. (Caesalpiniaceae) [12.7 microg/ml], Croton scheffleri Pax (Euphorbiaceae) [13.7 microg/ml], Hymenodactyon parvifolium Brig (Rubiaceae) [13.4 microg/ml], Kigelia Africana L. (Bignoniaceae) [7.2 microg/ml], and Ocimum suave Oliv. (Labiatae) [16.7 microg/ml]. Twelve plants gave LC(50) values between 21 and 50 microg/ml, 11 plants gave LC(50) values between 50 and 100 microg/ml, and 18 plants gave LC(50) values greater than 100 microg/ml.

Item Type: Article
Keywords: Brine Shrimp Test, Toxicity Evaluation, Traditional Antifungal Plants
Subjects: Health Systems > Surveillance, monitoring & evaluation
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 26 Mar 2013 07:18
Last Modified: 26 Mar 2013 07:18
URI: http://ihi.eprints.org/id/eprint/1259

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