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An Assessment of Orofacial Clefts in Tanzania.

Manyama, M., Rolian, C., Gilyoma, J., Magori, C. C., Mjema, K., Mazyala, E., Kimwaga, E. and Hallgrimsson, B. (2011) An Assessment of Orofacial Clefts in Tanzania. BMC oral health, 11. ISSN 1472-6831

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Abstract

Clefts of the lip (CL), the palate (CP), or both (CLP) are the most common orofacial congenital malformations found among live births, accounting for 65% of all head and neck anomalies. The frequency and pattern of orofacial clefts in different parts of the world and among different human groups varies widely. Generally, populations of Asian or Native American origin have the highest prevalence, while Caucasian populations show intermediate prevalence and African populations the lowest. To date, little is known regarding the epidemiology and pattern of orofacial clefts in Tanzania. A retrospective descriptive study was conducted at Bugando Medical Centre to identify all children with orofacial clefts that attended or were treated during a period of five years. Cleft lip and/or palate records were obtained from patient files in the Hospital's Departments of Surgery, Paediatrics and medical records. Age at presentation, sex, region of origin, type and laterality of the cleft were recorded. In addition, presence of associated congenital anomalies or syndromes was recorded. A total of 240 orofacial cleft cases were seen during this period. Isolated cleft lip was the most common cleft type followed closely by cleft lip and palate (CLP). This is a departure from the pattern of clefting reported for Caucasian and Asian populations, where CLP or isolated cleft palate is the most common type. The distribution of clefts by side showed a statistically significant preponderance of the left side (43.7%) (χ2 = 92.4, p < 0.001), followed by the right (28.8%) and bilateral sides (18.3%). Patients with isolated cleft palate presented at very early age (mean age 1.00 years, SE 0.56). Associated congenital anomalies were observed in 2.8% of all patients with orofacial clefts, and included neural tube defects, Talipes and persistent ductus arteriosus. Unilateral orofacial clefts were significantly more common than bilateral clefts; with the left side being the most common affected side. Most of the other findings did not show marked differences with orofacial cleft distributions in other African populations.

Item Type: Article
Keywords: Orofacial Clefts, Congenital Malformations, Cleft Lip, Cleft Palate, Treatment, Neural Tube Defects, Congenital Anomalies, Mwanza, Tanzania
Subjects: Maternal & Neonatal Health > Neonatal Health
Non-communicable disease (NCD) > Disability
Divisions: Catholic University of Health and Allied Sciences (CUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 22 May 2013 09:00
Last Modified: 22 May 2013 09:00
URI: http://ihi.eprints.org/id/eprint/1389

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