Idindili, B., Masanja, H., Urassa, H., Bunini, W., van Jaarsveld, P., Aponte, J. J., Kahigwa, E., Mshinda, H., Ross, D. and Schellenberg, D. M. (2007) Randomized controlled safety and efficacy trial of 2 vitamin A supplementation schedules in Tanzanian infants. The American journal of clinical nutrition, 85 (5). pp. 1312-1319. ISSN 0002-9165
Available under License Creative Commons Attribution Non-commercial.
Vitamin A supplementation reduces morbidity and mortality in children living in areas endemic for vitamin A deficiency. Routine vitamin A supplementation usually starts only at age 9 mo, but high rates of illness and mortality are seen in the first months of life.
The objective of the study was to evaluate the safety and efficacy of vitamin A supplementation at the same time as routine vaccination in infants aged 1-3 mo.
We recruited 780 newborn infants and their mothers to a randomized double-blind controlled trial in Ifakara in southern Tanzania. In one group, mothers received 60,000 microg vitamin A palmitate shortly after delivery, and their infants received 7500 microg at the same time as vaccinations given at approximately 1, 2, and 3 mo of age. In the other group, mothers received a second 60,000-microg dose when their infant was aged 1 mo, and their infants received 15,000 microg at the same time as the routine vaccinations. VAD was defined as a modified relative dose-response test result of >or=0.060.
High-dose vitamin A supplementation was well tolerated. The relative risk of VAD at 6 mo in the high-dose group compared with the lower dose group was 0.91 (95% CI: 0.76, 1.09; P=0.32). Serum retinol and incidence of illness did not differ significantly between the 2 groups. Some vitamin A capsules degraded toward the end of the study.
Doubling the doses of vitamin A to mothers and their young infants is safe but unlikely to reduce short-term morbidity or to substantially enhance the biochemical vitamin A status of infants at age 6 mo. The stability of vitamin A capsules merits further investigation.
|Keywords:||Vitamin A, supplementation, safety, mortality, morbidity Tanzania, infants, children|
|Subjects:||Nutrition & food security > Undernutrition|
|Divisions:||Ifakara Health Institute > Biomedical|
|Depositing User:||Mr Joseph Madata|
|Date Deposited:||18 Sep 2012 09:42|
|Last Modified:||18 Sep 2012 09:42|
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