ehealth digital library

Digital library of
the Tanzania
health
community

Cytophilic Antibodies to Plasmodium Falciparum Glutamate Rich Protein are Associated with Malaria Protection in an Area of Holoendemic Transmission.

Lusingu, J. P. A., Vestergaard, L. S., Alifrangis, M., Mmbando, B. P., Theisen, M., Kitua, A. Y., Lemnge, M. M. and Theander, T. G. (2005) Cytophilic Antibodies to Plasmodium Falciparum Glutamate Rich Protein are Associated with Malaria Protection in an Area of Holoendemic Transmission. Malaria journal, 4. p. 48. ISSN 1475-2875

[img]
Preview
PDF
John_PA_Lusingu.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (292kB)

Abstract

Several studies conducted in areas of medium or low malaria transmission intensity have found associations between malaria immunity and plasma antibody levels to glutamate rich protein (GLURP). This study was conducted to analyse if a similar relationship could be documented in an area of intense malaria transmission. A six month longitudinal study was conducted in an area of holoendemic malaria transmission in north-eastern Tanzania, where the incidence of febrile malaria decreased sharply by the age of three years, and anaemia constituted a significant part of the malaria disease burden. Plasma antibodies to glutamate rich protein (GLURP) were analysed and related with protection against malaria morbidity in models correcting for the effect of age. The risk of febrile malaria episodes was reduced significantly in children with measurable anti-GLURP IgG1 antibodies at enrollment [adjusted odds ratio: 0.39 (95% CI: 0.15, 0.99); P = 0.047]. Interestingly, there was an inverse relationship between the plasma anti-GLURP IgG1 and IgG3 levels and the levels of parasitaemia at enrollment. However, anti-GLURP IgG2 and IgG4 levels were not associated with reduction in parasite density. Similarly, antibody levels were not associated with haemoglobin levels or anaemia risk. Cytophilic IgG1 and IgG3 antibodies against R0-GLURP may contribute to the control of parasite multiplication and reduction in febrile malaria incidence in children living in an area of intense malaria transmission.

Item Type: Article
Keywords: Plasmodium Falciparum, Malaria, Anaemia, Plasma Antibodies, Glutamate Rich Protein, Tanzania
Subjects: Malaria > Surveillance, monitoring, evaluation
Malaria > Diagnosis & treatment
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 27 May 2013 06:04
Last Modified: 27 May 2013 06:04
URI: http://ihi.eprints.org/id/eprint/1476

Actions (login required)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics