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Patterns and Predictors of CD4 T-Cell Counts Among Children Born to HIV-Infected Women in Tanzania.

Kupka, R., Msamanga, G. I., Aboud, S., Manji, K. P., Duggan, C. and Fawzi, W. W. (2009) Patterns and Predictors of CD4 T-Cell Counts Among Children Born to HIV-Infected Women in Tanzania. Journal of tropical pediatrics, 55 (5). pp. 290-6. ISSN 1465-3664

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We assessed age-specific CD4 T-cell counts and their determinants among Tanzanian children born to HIV-infected mothers to address a major research gap. A total of 474 HIV-uninfected and 69 HIV-infected children were followed until age of 12 months. Maternal predictors were measured during pregnancy and child predictors at birth and throughout the follow up. Child CD4 T-cell counts were evaluated at the age of 3 months and subsequent 3-month intervals; they decreased linearly among HIV-infected (beta = -8 cells per week; 95% CI -12 to -4; P = 0.0003) and increased linearly among HIV-uninfected children (beta = 4 cells/week; 95% CI 2-7; P = 0.0008). Decreased child counts were predicted by low child anthropometry, maternal HIV stage > or =2, and maternal mid-upper arm circumference <27 cm among HIV-infected children; and by weight-for-height <-2 z-score, maternal HIV stage > or =2, maternal erythrocyte sedimentation rate <81 mm/h and maternal haemoglobin <8.5 g/dl among HIV-uninfected children. The maternal and child predictors described may serve as intervention targets among HIV-exposed children.

Item Type: Article
Keywords: CD4, T-Cell, Children, HIV-infection, Maternal Health, Pregnancy, birth, Tanzania
Subjects: HIV > Surveillance
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 13 Nov 2013 12:17
Last Modified: 13 Nov 2013 12:17

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