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Blood Glucose as a Predictor of Mortality in Children Admitted to the Hospital with Febrile Illness in Tanzania.

Nadjm, B., Mtove, G., Amos, B., Hildenwall, H., Najjuka, A., Mtei, F., Todd, J. and Reyburn, H. (2013) Blood Glucose as a Predictor of Mortality in Children Admitted to the Hospital with Febrile Illness in Tanzania. The American journal of tropical medicine and hygiene. ISSN 1476-1645

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Abstract

Data from a prospective study of 3,319 children ages 2 months to 5 years admitted with febrile illness to a Tanzanian district hospital were analyzed to determine the relationship of blood glucose and mortality. Hypoglycemia (blood sugar < 2.5 mmol/L and < 45 mg/dL) was found in 105 of 3,319 (3.2%) children at admission, and low-normal blood glucose (2.5-5 mmol/L and 45-90 mg/dL) was found in 773 of 3,319 (23.3%) children. Mortality was inversely related to admission blood sugar; compared with children with an admission blood glucose of > 5 mmol/L, the adjusted odds of dying were 3.3 (95% confidence interval = 2.1-5.2) and 9.8 (95% confidence interval = 5.1-19.0) among children with admission blood glucose 2.5-5 and < 2.5 mmol/L, respectively. Receiver operating characteristic (ROC) analysis suggested an optimal cutoff for admission blood sugar of < 5 mmol/L in predicting mortality (sensitivity = 57.7%, specificity = 75.2%). A cutoff for admission blood glucose of < 5 mmol/L represents a simple and clinically useful predictor of mortality in children admitted with severe febrile illness to hospital in resource-poor settings.

Item Type: Article
Keywords: Blood Glucose, Mortality in Children, Febrile Illness, Hospital, Malaria, Plasmodium falciparum, Tanzania
Subjects: Health Systems > Surveillance, monitoring & evaluation
Divisions: National Institute for Medical Research
Depositing User: Mr Joseph Madata
Date Deposited: 22 Sep 2014 05:59
Last Modified: 22 Sep 2014 05:59
URI: http://ihi.eprints.org/id/eprint/1750

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