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Outdoor Mosquito Control Using Odour-Baited Devices: Development and Evaluation of a Potential New Strategy to Complement Indoor Malaria Prevention Methods

Okumu, F. O. , Sumaye, R. D. , Matowo, N. S. , Mwangungulu, S. P. , Kaindoa, E. W. , Moshi, I. R. , Madumla, E. P. and Lwetoijera, D. W. (2013) Outdoor Mosquito Control Using Odour-Baited Devices: Development and Evaluation of a Potential New Strategy to Complement Indoor Malaria Prevention Methods. MalariaWorld Journal, 4 (8). ISSN 2214-4374

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Abstract

A considerable effort is currently underway to develop a malaria vaccine based on live Plasmodium falciparum sporozoites. The first requisite of a sporozoite vaccine is the guarantee of parasite arrest prior to the onset of the pathogenic blood stage. Immunisation with genetically attenuated parasites (GAP) that arrest in the liver forms a promising approach. Work in this thesis describes the development and characterisation of a P. berghei Δb9Δslarp GAP that fully arrests in the liver. Immunisation of multiple mouse strains with low numbers of Δb9Δslarp GAP resulted in sterile protection. The Δb9Δslarp GAP is there- fore the leading GAP vaccine candidate. Work in this the- sis further describes the effect of varying the parameters of sporozoite inoculation on parasite liver load. These findings provide a rationale for the design of clinical trials aimed at the administration of live attenuated P. falciparum sporozoites.

Item Type: Article
Keywords: Outdoor Mosquito Control, Odour-Baited Devices, Malaria, Vector Control, Insecticide Treated Nets, Tanzania
Subjects: Malaria > Vector control
Divisions: Ifakara Health Institute > Environmental
Depositing User: Mr Joseph Madata
Date Deposited: 01 Aug 2013 06:50
Last Modified: 01 Aug 2013 06:50
URI: http://ihi.eprints.org/id/eprint/1838

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