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The Role of Diabetes Co-Morbidity for Tuberculosis Treatment Outcomes: A Prospective Cohort Study from Mwanza, Tanzania.

Faurholt-Jepsen, D., Range, N., Praygod, G., Kidola, J., Faurholt-Jepsen, M., Aabye, M. G., Changalucha, J., Christensen, D. L., Martinussen, T., Krarup, H., Witte, D. R., Andersen, Å. B. and Friis, H. (2012) The Role of Diabetes Co-Morbidity for Tuberculosis Treatment Outcomes: A Prospective Cohort Study from Mwanza, Tanzania. BMC infectious diseases, 12. p. 165. ISSN 1471-2334

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Abstract

Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period. Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery. Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p < 0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively. TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.

Item Type: Article
Keywords: Tuberculosis, Diabetes, Treatment Outcome, Anthropometry, Haemoglobin, Grip Strength
Subjects: Non-communicable disease (NCD) > Diabetes
Tuberculosis > Treatment
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 28 Aug 2013 09:49
Last Modified: 28 Aug 2013 09:49
URI: http://ihi.eprints.org/id/eprint/1955

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