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Comparison of Overnight Pooled and Standard Sputum Collection Method for Patients with Suspected Pulmonary Tuberculosis in Northern Tanzania.

Mpagama, S. G., Mtabho, C., Mwaigwisya, S., Mleoh, L. J., Boer, I. M. S.-d., Heysell, S. K., Houpt, E. R. and Kibiki, G. S. (2012) Comparison of Overnight Pooled and Standard Sputum Collection Method for Patients with Suspected Pulmonary Tuberculosis in Northern Tanzania. Tuberculosis research and treatment, 2012. p. 128057. ISSN 2090-1518

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Abstract

In Tanzania sputum culture for tuberculosis (TB) is resource intensive and available only at zonal facilities. In this study overnight pooled sputum collection technique was compared with standard spot morning collection among pulmonary TB suspects at Kibong'oto National TB Hospital in Tanzania. A spot sputum specimen performed at enrollment, an overnight pooled sputum, and single morning specimen were collected from 50 subjects and analyzed for quality, quantity, and time to detection in Bactec MGIT system. Forty-six (92%) subjects' overnight pooled specimens had a volume ≥5 mls compared to 37 (37%) for the combination of spot and single morning specimens (P < 0.001). Median time to detection was 96 hours (IQR 87-131) for the overnight pooled specimens compared to 110.5 hours (IQR is 137 right 137-180) for the combination of both spot and single morning specimens (P = 0.001). In our setting of limited TB culture capacity, we recommend a single pooled sputum to maximize yield and speed time to diagnosis.

Item Type: Article
Keywords: Pulmonary Tuberculosis, HIV, Treatment, Hospital, Sputum Samples, Mycobacterium Tuberculosis, Kilimanjaro, Tanzania
Subjects: Tuberculosis > Diagnosis
Divisions: Kilimanjaro Christian Medical Centre
Depositing User: Mr Joseph Madata
Date Deposited: 12 May 2014 12:20
Last Modified: 12 May 2014 12:20
URI: http://ihi.eprints.org/id/eprint/1970

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