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CD4 Lymphocyte Dynamics in Tanzanian Pulmonary Tuberculosis Patients with and without HIV Co-Infection.

Andersen, A. B., Range, N. S., Changalucha, J., Praygod, G., Kidola, J., Faurholt-Jepsen, D., Krarup, H., Grewal, H. M. S. and Friis, H. (2012) CD4 Lymphocyte Dynamics in Tanzanian Pulmonary Tuberculosis Patients with and without HIV Co-Infection. BMC infectious diseases, 12. p. 66. ISSN 1471-2334

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The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported. CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area. Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment, whereas those prescribed ART between baseline and 2 months, and between 2 and 5 months increased by 69 (22;117) and 110 (52; 168) CD4 cells per μL after 5 months. The increase in circulating CD4 levels observed in PTB in patients is acquired after 2 months of treatment irrespective of HIV status. Initiation of ART is the strongest factor correlated with CD4 increase during TB treatment.

Item Type: Article
Keywords: Pulmonary Tuberculosis, HIV, CD4 Cells, TB Treatment
Subjects: HIV > Treatment
Tuberculosis > Diagnosis
Tuberculosis > Treatment
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 26 Aug 2013 07:23
Last Modified: 26 Aug 2013 07:23

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