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Anemia in Adults with Tuberculosis is Associated with HIV and Anthropometric Status in Dar es Salaam, Tanzania.

Saathoff, E., Villamor, E., Mugusi, F., Bosch, R. J., Urassa, W. and Fawzi, W. W. (2011) Anemia in Adults with Tuberculosis is Associated with HIV and Anthropometric Status in Dar es Salaam, Tanzania. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 15 (7). pp. 925-32. ISSN 1815-7920

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Abstract

Tuberculosis (TB) infected adults attending out-patient TB clinics in Dar es Salaam, Tanzania. To examine the association of anemia with human immunodeficiency virus (HIV) co-infection, indicators of socio-economic status (SES) and anthropometric status in TB-infected adults. Cross-sectional data collection during screening for a clinical trial. Overall, 750 females and 1693 males participated in this study, of whom respectively 49% and 24% were co-infected with HIV-1. Hemoglobin levels were significantly lower in females than in males and in HIV-positive than in HIV-negative participants. HIV co-infection in this antiretroviral-naïve population was also associated with severe anemia (hemoglobin < 85 g/l) in both women (prevalence ratio [PR] = 2.07, 95%CI 1.65-2.59) and men (PR 3.45, 95%CI 2.66-4.47). Although severe anemia was negatively associated with indicators of SES, especially in males, adjustment for SES indicators only marginally changed its association with HIV co-infection. In both sexes, anemia was inversely associated with anthropometric status, independently of HIV infection and SES. Among TB-infected adults, anemia is strongly associated with HIV co-infection and anthropometric status, independently of SES indicators. As anemia is a risk factor for morbidity and mortality in both infections, the management of anemia in TB-HIV co-infected patients warrants special attention.

Item Type: Article
Keywords: Pulmonary tuberculosis, Anemia; HIV, Anthropometric status, Socio-economic status
Subjects: HIV > Surveillance
Tuberculosis > Surveillance
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 07 Jan 2014 09:01
Last Modified: 07 Jan 2014 09:01
URI: http://ihi.eprints.org/id/eprint/2269

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