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Vitamin A and Vitamin B-12 Concentrations in Relation to Mortality and Morbidity among Children Born to HIV-Infected Women.

Chatterjee, A., Bosch, R. J., Hunter, D. J., Manji, K., Msamanga, G. I. and Fawzi, W. W. (2010) Vitamin A and Vitamin B-12 Concentrations in Relation to Mortality and Morbidity among Children Born to HIV-Infected Women. Journal of tropical pediatrics, 56 (1). pp. 27-35. ISSN 1465-3664

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Abstract

Vitamin A supplementation starting at 6 months of age is an important child survival intervention; however, not much is known about the association between vitamin A status before 6 months and mortality among children born to HIV-infected women. Plasma concentrations of vitamins A and B-12 were available at 6 weeks of age (n = 576 and 529, respectively) for children born to HIV-infected women and they were followed up for morbidity and survival status until 24 months after birth. Children in the highest quartile of vitamin A had a 49% lower risk of death by 24 months of age compared to the lowest quartile (HR: 0.51, 95% CI: 0.29-0.90; P-value for trend = 0.01). Higher vitamin A levels were protective in the sub-groups of HIV-infected and un-infected children but this was statistically significant only in the HIV-uninfected subgroup. Higher vitamin A concentrations in plasma are protective against mortality in children born to HIV-infected women.

Item Type: Article
Keywords: Vitamin A, Vitamin B-12, Mortality, Morbidity, HIV-Infected Women, sub-Saharan Africa
Subjects: Nutrition & food security > Vitamin A
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 27 Nov 2013 10:58
Last Modified: 27 Nov 2013 10:58
URI: http://ihi.eprints.org/id/eprint/2296

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