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High Rate of Fatal Cases of Pediatric Septicemia Caused by Gram-Negative Bacteria with Extended-Spectrum Beta-lactamases in Dar es Salaam, Tanzania.

Blomberg, B., Jureen, R., Manji, K. P., Tamim, B. S., Mwakagile, D. S. M., Urassa, W. K., Fataki, M., Msangi, V., Tellevik, M. G., Maselle, S. Y. and Langeland, N. (2005) High Rate of Fatal Cases of Pediatric Septicemia Caused by Gram-Negative Bacteria with Extended-Spectrum Beta-lactamases in Dar es Salaam, Tanzania. Journal of clinical microbiology, 43 (2). pp. 745-9. ISSN 0095-1137

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Abstract

Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.

Item Type: Article
Keywords: Pediatric Septicemia, Gram-Negative, Bacteria, Escherichia coli, Klebsiella pneumoniae, pediatric septicemia, Tanzania
Subjects: Emerging and Re-emerging Infectious Diseases
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 05 Dec 2013 06:14
Last Modified: 05 Dec 2013 06:14
URI: http://ihi.eprints.org/id/eprint/2298

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