ehealth digital library

Digital library of
the Tanzania

Malaria and Fetal Growth Alterations in the 3(rd) Trimester of Pregnancy: A Longitudinal Ultrasound Study.

Schmiegelow, C., Minja, D., Oesterholt, M., Pehrson, C., Suhrs, H. E., Boström, S., Lemnge, M., Magistrado, P., Rasch, V., Nielsen, B. B., Lusingu, J. and Theander, T. G. (2013) Malaria and Fetal Growth Alterations in the 3(rd) Trimester of Pregnancy: A Longitudinal Ultrasound Study. PloS one, 8 (1). e53794. ISSN 1932-6203

Christentze_Schmiegelow.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (298kB)


Pregnancy associated malaria is associated with decreased birth weight, but in-utero evaluation of fetal growth alterations is rarely performed. The objective of this study was to investigate malaria induced changes in fetal growth during the 3(rd) trimester using trans-abdominal ultrasound. An observational study of 876 pregnant women (398 primi- and secundigravidae and 478 multigravidae) was conducted in Tanzania. Fetal growth was monitored with ultrasound and screening for malaria was performed regularly. Birth weight and fetal weight were converted to z-scores, and fetal growth evaluated as fetal weight gain from the 26th week of pregnancy. Malaria infection only affected birth weight and fetal growth among primi- and secundigravid women. Forty-eight of the 398 primi- and secundigravid women had malaria during pregnancy causing a reduction in the newborns z-score of -0.50 (95% CI: -0.86, -0.13, P = 0.008, multiple linear regression). Fifty-eight percent (28/48) of the primi- and secundigravidae had malaria in the first half of pregnancy, but an effect on fetal growth was observed in the 3(rd) trimester with an OR of 4.89 for the fetal growth rate belonging to the lowest 25% in the population (95%CI: 2.03-11.79, P<0.001, multiple logistic regression). At an individual level, among the primi- and secundigravidae, 27% experienced alterations of fetal growth immediately after exposure but only for a short interval, 27% only late in pregnancy, 16.2% persistently from exposure until the end of pregnancy, and 29.7% had no alterations of fetal growth. The effect of malaria infections was observed during the 3(rd) trimester, despite infections occurring much earlier in pregnancy, and different mechanisms might operate leading to different patterns of growth alterations. This study highlights the need for protection against malaria throughout pregnancy and the recognition that observed changes in fetal growth might be a consequence of an infection much earlier in pregnancy.

Item Type: Article
Keywords: Malaria, Malaria, Fetal growth, Pregnant woman, Fetal growth, Birth weight, Tanzania
Subjects: Malaria > Surveillance, monitoring, evaluation
Maternal & Neonatal Health > Antenatal care
Divisions: National Institute for Medical Research
Depositing User: Mr Joseph Madata
Date Deposited: 29 Jan 2014 07:58
Last Modified: 29 Jan 2014 07:58

Actions (login required)

Edit Item Edit Item


Downloads per month over past year

View more statistics