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Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania.

Mugittu, K., Genton, B., Mshinda, H. and Beck, H. P. (2006) Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. Malaria journal, 5. p. 126. ISSN 1475-2875 (In Press)

1475-2875-5-126.pdf - Accepted Version
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Artemisinin-based combination therapies (ACTs) are recommended for use against uncomplicated malaria in areas of multi-drug resistant malaria, such as sub-Saharan Africa. However, their long-term usefulness in these high transmission areas remains unclear. It has been suggested that documentation of the S769N PfATPase6 mutations may indicate an emergence of artemisinin resistance of Plasmodium falciparum in the field. The present study assessed PfATPase6 mutations (S769N and A623E) in 615 asymptomatic P. falciparum infections in Tanzania but no mutant genotype was detected. This observation suggests that resistance to artemisinin has not yet been selected in Tanzania, supporting the Ministry of Health's decision to adopt artemether+lumefantrine as first-line malaria treatment. The findings recommend further studies to assess PfATPase6 mutations in sentinel sites and verify their usefulness in monitoring emergency of ACT resistance.

Item Type: Article
Keywords: Molecular biology,Plasmodium falciparum, artemisinin in Tanzania.
Subjects: Malaria > Surveillance, monitoring, evaluation
Malaria > Diagnosis & treatment
Divisions: Ifakara Health Institute > Biomedical
Depositing User: Mr Joseph Madata
Date Deposited: 10 Sep 2012 08:08
Last Modified: 10 Sep 2012 08:08

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