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How Does Population Viral Load Vary with the Evolution of a Large HIV Epidemic in sub-Saharan Africa?

Abu-Raddad, L. J. and Awad, S. F. (2014) How Does Population Viral Load Vary with the Evolution of a Large HIV Epidemic in sub-Saharan Africa? AIDS (London, England). ISSN 1473-5571

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Abstract

Using mathematical modelling, we described the temporal evolution of population HIV-1 viral load in Tanzania throughout the epidemic. Population log10 viral load was found to be stable and not sensitive to epidemic dynamics. However, even modest increases in antiretroviral therapy (ART) coverage were reflected as appreciable reductions in population log10 viral load. As ART coverage expands in sub-Saharan Africa, population log10 viral load will increasingly become a powerful proxy for monitoring ART implementation and HIV incidence trends. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.

Item Type: Article
Keywords: HIV, Viral load, Population, Antiretroviral therapy (ART), sub-Saharan Africa
Subjects: HIV > Surveillance
HIV > Treatment
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 18 Feb 2014 06:19
Last Modified: 18 Feb 2014 06:19
URI: http://ihi.eprints.org/id/eprint/2475

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