ehealth digital library

Digital library of
the Tanzania
health
community

Negative Cross Resistance Mediated by Co-treated bed nets: A Potential Means of Restoring Pyrethroid-susceptibility to Malaria Vectors.

White, M. T., Lwetoijera, D., Marshall, J., Caron-Lormier, G., Bohan, D. A., Denholm, I. and Devine, G. J. (2014) Negative Cross Resistance Mediated by Co-treated bed nets: A Potential Means of Restoring Pyrethroid-susceptibility to Malaria Vectors. PloS one, 9 (5). e95640. ISSN 1932-6203

[img]
Preview
PDF
Michael_T._White.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (578kB)

Abstract

Insecticide-treated nets and indoor residual spray programs for malaria control are entirely dependent on pyrethroid insecticides. The ubiquitous exposure of Anopheles mosquitoes to this chemistry has selected for resistance in a number of populations. This threatens the sustainability of our most effective interventions but no operationally practicable way of resolving the problem currently exists. One innovative solution involves the co-application of a powerful chemosterilant (pyriproxyfen or PPF) to bed nets that are usually treated only with pyrethroids. Resistant mosquitoes that are unaffected by the pyrethroid component of a PPF/pyrethroid co-treatment remain vulnerable to PPF. There is a differential impact of PPF on pyrethroid-resistant and susceptible mosquitoes that is modulated by the mosquito's behavioural response at co-treated surfaces. This imposes a specific fitness cost on pyrethroid-resistant phenotypes and can reverse selection. The concept is demonstrated using a mathematical model.

Item Type: Article
Keywords: Co-Treated Bed Nets, Malaria Vectors, Indoor residual spray, Malaria control, Mosquito
Subjects: Malaria > Vector control
Divisions: Ifakara Health Institute > Environmental
Depositing User: Mr Joseph Madata
Date Deposited: 12 May 2014 12:15
Last Modified: 12 May 2014 12:15
URI: http://ihi.eprints.org/id/eprint/2638

Actions (login required)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics