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Placental Malaria Is Rare Among Zanzibari Pregnant Women Who Did Not Receive Intermittent Preventive Treatment in Pregnancy.

Plotkin, M., Said, K., Msellem, M. I., Chase, R. P., Hendler, N., Khamis, A. R., Roman, E., Kitojo, C., Schwartz, A. C., Gutman, J. and McElroy, P. D. (2014) Placental Malaria Is Rare Among Zanzibari Pregnant Women Who Did Not Receive Intermittent Preventive Treatment in Pregnancy. The American journal of tropical medicine and hygiene. ISSN 1476-1645

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Abstract

Zanzibar has transitioned from malaria control to the pre-elimination phase, and the continued need for intermittent preventive treatment during pregnancy (IPTp) has been questioned. We conducted a prospective observational study to estimate placental malaria positivity rate among women who did not receive IPTp with sulfadoxine-pyrimethamine. A convenience sample of pregnant women was enrolled from six clinics on the day of delivery from August of 2011 to September of 2012. Dried placental blood spot specimens were analyzed by polymerase chain reaction (PCR); 9 of 1,349 specimens (0.7%; precision estimate = 0.2-1.1%) were PCR-positive for Plasmodium falciparum. Placental infection was detected on both Pemba (N = 3) and Unguja (N = 6). Placental malaria positivity in Zanzibar was low, even in the absence of IPTp. It may be reasonable for the Ministry of Health to consider discontinuing IPTp, intensifying surveillance efforts, and promoting insecticide-treated nets and effective case management of malaria in pregnancy.

Item Type: Article
Keywords: Intermittent preventive treatment, Malaria, Pregnancy, Zanzibari, Tanzania
Subjects: Malaria > Diagnosis & treatment
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 17 Jun 2014 07:21
Last Modified: 17 Jun 2014 07:21
URI: http://ihi.eprints.org/id/eprint/2681

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