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Immunological markers of childhood fevers in an area of intense and perennial malaria transmission.

Hurt, N., Thein, M., Smith, T., Bordmann, G., Gallati, H., Drees, N., Tanner, M. and Weiss, N. (1995) Immunological markers of childhood fevers in an area of intense and perennial malaria transmission. Clinical and experimental immunology, 100 (1). pp. 59-66. ISSN 0009-9104

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In order to describe presumed paediatric malaria on a cell-immunological basis, the soluble receptors of IL-2 (sIL-2R) and tumour necrosis factor (sTNF-R55 and sTNF-R75) were quantified in highly exposed young Tanzanian children. Sera were obtained from 66 acute and 72 reported febrile patients during health post consultations and follow-ups and from 68 community controls. Levels of sIL-2R, sTNF-R55 and sTNF-R75 were significantly elevated during fever attacks, especially in very young children. Soluble TNF-R75 levels were most stable and those of sTNF-R55 least. Levels of sTNF-R55 were related to the magnitude of fever and thus appeared to reflect attack severity. Levels of sTNF-R75 were highly significantly associated with parasite density, indicating that this response is malaria-specific. The present study indicates that sTNF-R75 levels could become a useful immunological tool in malaria intervention studies, as they reflect changes in malaria-specific immune responses. Future studies should validate this potential in different endemic settings.

Item Type: Article
Keywords: Immunology, children illness, fever, perennial malaria, malaria transmission
Subjects: Biomedical Science > Immunology
Malaria > Surveillance, monitoring, evaluation
Malaria > Vaccines
Divisions: Ifakara Health Institute > Biomedical
Depositing User: Mr Joseph Madata
Date Deposited: 01 Aug 2012 07:08
Last Modified: 16 Aug 2012 15:57

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