Hurt, N., Thein, M., Smith, T., Bordmann, G., Gallati, H., Drees, N., Tanner, M. and Weiss, N. (1995) Immunological markers of childhood fevers in an area of intense and perennial malaria transmission. Clinical and experimental immunology, 100 (1). pp. 59-66. ISSN 0009-9104
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In order to describe presumed paediatric malaria on a cell-immunological basis, the soluble receptors of IL-2 (sIL-2R) and tumour necrosis factor (sTNF-R55 and sTNF-R75) were quantified in highly exposed young Tanzanian children. Sera were obtained from 66 acute and 72 reported febrile patients during health post consultations and follow-ups and from 68 community controls. Levels of sIL-2R, sTNF-R55 and sTNF-R75 were significantly elevated during fever attacks, especially in very young children. Soluble TNF-R75 levels were most stable and those of sTNF-R55 least. Levels of sTNF-R55 were related to the magnitude of fever and thus appeared to reflect attack severity. Levels of sTNF-R75 were highly significantly associated with parasite density, indicating that this response is malaria-specific. The present study indicates that sTNF-R75 levels could become a useful immunological tool in malaria intervention studies, as they reflect changes in malaria-specific immune responses. Future studies should validate this potential in different endemic settings.
|Keywords:||Immunology, children illness, fever, perennial malaria, malaria transmission|
|Subjects:||Biomedical Science > Immunology
Malaria > Surveillance, monitoring, evaluation
Malaria > Vaccines
|Divisions:||Ifakara Health Institute > Biomedical|
|Depositing User:||Mr Joseph Madata|
|Date Deposited:||01 Aug 2012 07:08|
|Last Modified:||16 Aug 2012 15:57|
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