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Imaging correlates of molecular signatures in oligodendrogliomas.

Megyesi, J. F., Kachur, E., Lee, D. H., Zlatescu, M. C., Betensky, R. A., Forsyth, P. A., Okada, Y., Sasaki, H., Mizoguchi, M., Louis, D. N. and Cairncross, J. G. (2004) Imaging correlates of molecular signatures in oligodendrogliomas. Clinical cancer research : an official journal of the American Association for Cancer Research, 10 (13). pp. 4303-4306. ISSN 1078-0432

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Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T(1) images and mixed intensity signal on T(1) and T(2). Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.

Item Type: Article
Keywords: Molecular biology, oligodendrogliomas, brain, genotypes, chromosom
Subjects: Biomedical Science > Molecular biology
Divisions: Ifakara Health Institute > Biomedical
Depositing User: Mr Joseph Madata
Date Deposited: 08 Sep 2012 21:13
Last Modified: 08 Sep 2012 21:13

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