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Red blood cell indices and Prevalence of Hemoglobinopathies and Glucose 6 Phosphate Dehydrogenase Deficiencies in Male Tanzanian Residents of Dar es Salaam

Mwakasungula, S., Schindler, T., Jongo, S., Moreno, E., Kamaka, K., Mohammed, M., Joseph, S., Rashid, R., Athuman, T., Tumbo, A. M., Hamad, A., Lweno, O., Tanner, M., Shekalaghe, S. and Daubenberge, C. A. (2014) Red blood cell indices and Prevalence of Hemoglobinopathies and Glucose 6 Phosphate Dehydrogenase Deficiencies in Male Tanzanian Residents of Dar es Salaam. International Journal of Molecular Epidemiology and Genetics, IJMEG, 5 (4). pp. 185-194. ISSN 1948-1756

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Abstract

Hemoglobinopathies, disorders of hemoglobin structure and production, are one of the most common monogenic disorders in humans. Glucose 6 phosphate dehydrogenase deficiency (G6PD) is an inherited enzymopathy resulting in increased oxygen stress susceptibility of red blood cells. The distributions of these genetic traits in populations living in tropical and subtropical regions where malaria has been or is still present are thought to result from survival advantage against severe life threatening malaria disease. 384 male Tanzanian volunteers residing in Dar es Salaam were typed for G6PD, sickle cell disease and α-thalassemia. The most prominent red blood cell polymorphism was heterozygous α+-thalassemia (37.8%), followed by the G6PD(A) deficiency (16.4%), heterozygous sickle cell trait (15.9%), G6PD(A-) deficiency (13.5%) and homozygous α+-thalassemia (5.2%). 35%, 45%, 17% and 3% of these volunteers were carriers of wild type gene loci, one, two or three of these hemoglobinopathies, respectively. We find that using a cut off value of 28.6 pg. for mean corpuscular hemoglobin (MCH), heterozygous α+-thalassemia can be predicted with a sensitivity of 84% and specificity of 72% in this male population. All subjects carrying homozygous α+-thalassemia were identified based on their MCH value < 28.6 pg.

Item Type: Article
Keywords: Sickle cell, glucose, dehydrogenase, α-thalassemia, screening, mean corpuscular hemoglobin, whole blood count, Tanzania, malaria
Subjects: Biomedical Science > Immunology
Divisions: Ifakara Health Institute > Biomedical
Depositing User: Mr Joseph Madata
Date Deposited: 05 Mar 2015 08:52
Last Modified: 05 Mar 2015 08:52
URI: http://ihi.eprints.org/id/eprint/3154

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