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African Glucose-6-Phosphate Dehydrogenase Alleles Associated with Protection from Severe Malaria in Heterozygous Females in Tanzania.

Manjurano, A., Sepulveda, N., Nadjm, B., Mtove, G., Wangai, H., Maxwell, C., Olomi, R., Reyburn, H., Riley, E. M., Drakeley, C. J. and Clark, T. G. (2015) African Glucose-6-Phosphate Dehydrogenase Alleles Associated with Protection from Severe Malaria in Heterozygous Females in Tanzania. PLoS genetics, 11 (2). e1004960. ISSN 1553-7404

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Abstract

X-linked Glucose-6-phosphate dehydrogenase (G6PD) A- deficiency is prevalent in sub-Saharan Africa populations, and has been associated with protection from severe malaria. Whether females and/or males are protected by G6PD deficiency is uncertain, due in part to G6PD and malaria phenotypic complexity and misclassification. Almost all large association studies have genotyped a limited number of G6PD SNPs (e.g. G6PD202 / G6PD376), and this approach has been too blunt to capture the complete epidemiological picture. Here we have identified 68 G6PD polymorphisms and analysed 29 of these (i.e. those with a minor allele frequency greater than 1%) in 983 severe malaria cases and controls in Tanzania. We establish, across a number of SNPs including G6PD376, that only female heterozygotes are protected from severe malaria. Haplotype analysis reveals the G6PD locus to be under balancing selection, suggesting a mechanism of protection relying on alleles at modest frequency and avoiding fixation, where protection provided by G6PD deficiency against severe malaria is offset by increased risk of life-threatening complications. Our study also demonstrates that the much-needed large-scale studies of severe malaria and G6PD enzymatic function across African populations require the identification and analysis of the full repertoire of G6PD genetic markers.

Item Type: Article
Keywords: Glucose-6-phosphate dehydrogenase, Malaria, Heterozygous females, (G6PD) A- deficiency
Subjects: ?? BS1 ??
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Divisions: ?? kcmc ??
Depositing User: Users 61 not found.
Date Deposited: 11 Mar 2015 06:34
Last Modified: 11 Mar 2015 06:34
URI: http://ihi.eprints.org/id/eprint/3157

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