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Maturation and Mip-1β Production of Cytomegalovirus-Specific T Cell Responses in Tanzanian Children, Adolescents and Adults: Impact by HIV and Mycobacterium Tuberculosis Co-Infections.

Portevin, D., Moukambi, F., Mpina, M., Bauer, A., Haraka, F., Chachage, M., Metzger, P., Saathoff, E., Clowes, P., Ntinginya, N. E., Rachow, A., Hoelscher, M., Reither, K., Daubenberger, C. A. and Geldmacher, C. (2015) Maturation and Mip-1β Production of Cytomegalovirus-Specific T Cell Responses in Tanzanian Children, Adolescents and Adults: Impact by HIV and Mycobacterium Tuberculosis Co-Infections. PloS one, 10 (5). e0126716. ISSN 1932-6203

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Abstract

It is well accepted that aging and HIV infection are associated with quantitative and functional changes of CMV-specific T cell responses. We studied here the expression of Mip-1β and the T cell maturation marker CD27 within CMVpp65-specific CD4+ and CD8+ T cells in relation to age, HIV and active Tuberculosis (TB) co-infection in a cohort of Tanzanian volunteers (≤16 years of age, n = 108 and ≥18 years, n = 79). Independent of HIV co-infection, IFNγ+ CMVpp65-specific CD4+ T cell frequencies increased with age. In adults, HIV co-infection further increased the frequencies of these cells. A high capacity for Mip-1β production together with a CD27low phenotype was characteristic for these cells in children and adults. Interestingly, in addition to HIV co-infection active TB disease was linked to further down regulation of CD27 and increased capacity of Mip-1β production in CMVpp65-specific CD4+ T cells. These phenotypic and functional changes of CMVpp65-specific CD4 T cells observed during HIV infection and active TB could be associated with increased CMV reactivation rates.

Item Type: Article
Keywords: Maturation and Mip-1β Production, CMV-specific T cell responses, HIV, Tuberculosis (TB) co-infection
Subjects: HIV > Surveillance
Tuberculosis > Diagnosis
Depositing User: Mr Joseph Madata
Date Deposited: 18 Nov 2015 07:49
Last Modified: 18 Nov 2015 07:49
URI: http://ihi.eprints.org/id/eprint/3240

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