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Absence of kdr resistance alleles in the Union of the Comoros,East Africa

Lee, Y., Olson, N., Yamasaki, Y., Chang, A., Marsden, C., Ouledi, A., Lanzaro, G. and Cornel, A. (2015) Absence of kdr resistance alleles in the Union of the Comoros,East Africa. F1000Research. ISSN 2046-1402

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Knockdown resistance (kdr) and CYP9K1 genotypes were detected by a MOLDI-TOF based SNP genotyping assay (Sequenom iPLEX) in samples of Anopheles gambiae collected at 13 sites throughout the Union of the Comoros and Dar es Salaam, Tanzania during February and March 2011. All A. gambiae specimens collected in the Comoros were homozygous for the susceptible kdr alleles (+/+) while 96% of A. gambiae from Dar es Salaam were homozygous for the East African kdr resistant genotype (E/E). In contrast, all specimens from Dar es Salaam and the Comoros were homozygous for the cyp3 allele (c3/c3) at the CYP9K1 locus; the locus has been implicated in metabolic resistance against pyrethroid insecticides in West Africa. All specimens had typical A. gambiae genotypes for SNPs within the divergence Islands on all three chromosomes. Although further spatial and temporal studies are needed, the distribution of kdr genotypes between the Comoros and Tanzania further supports isolation of the Comoros populations from A. gambiae populations on mainland Africa.

Item Type: Article
Keywords: Knockdown resistance, Comoros, Anopheles gambiae, Dar es Salaam, East African
Subjects: Malaria > Vector control
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 27 Jun 2016 05:54
Last Modified: 27 Jun 2016 05:54

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