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Nevirapine-Induced Hepatotoxicity in HIV Patients Attending Care and Treatment Clinics in Tanzania

Mafuru, M. (2015) Nevirapine-Induced Hepatotoxicity in HIV Patients Attending Care and Treatment Clinics in Tanzania. BAOJ HIV, 1 (1).

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Abstract

The aim of the study was to determine the prevalence of hepatotoxicity in HIV-infected patients using nevirapinecontaining antiretroviral drugs (ARVs) in comparison with those using efavirenz-based ARVs. HIV-infected patients who had been using ARVs for at least two weeks were recruited for the study. A total of 373 adult patients (224 taking nevirapine-based regimen and 149 taking efavirenzbased regimens) were screened for elevated liver aminotransferases as markers for liver toxicity. Mild to moderate hepatotoxicity was observed in 12.1% of patients who were using nevirapine compared to 4% of efavirenz users (P = 0.004). Hepatotoxicity was common (13.2%) in patients who had been using nevirapine for > 12 months than those who were using the same regimens (4.3%) for ≤ 12 months. Patients with CD4 cell count of > 250 cells/mm3 were 10 times more at risk of developing hepatotoxicity than patients with CD4 cell count of ≤ 250 cells/ mm3 . Age, sex, body mass index and duration of use of ARVs were not significantly associated with hepatotoxicity. Routine monitoring of liver aminotransferances should be conducted in patients taking nevirapine containing ARVs regimen, especially in patients with CD4 cell count of > 250 cells/mm3 .

Item Type: Article
Keywords: Hepatotoxicity, Nevirapine, ARVs, Liver enzymes.
Subjects: Emerging and Re-emerging Infectious Diseases
HIV > Treatment
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 27 Jun 2016 05:48
Last Modified: 27 Jun 2016 05:48
URI: http://ihi.eprints.org/id/eprint/3373

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