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Clostridium Difficile Infections among Adults and Children in Mwanza/Tanzania: is it an Underappreciated Pathogen among Immunocompromised Patients in sub-Saharan Africa?

Seugendo, M., Mshana, S. E., Hokororo, A., Okamo, B., Mirambo, M. M., von Müller, L., Gunka, K., Zimmermann, O. and Groß, U. (2015) Clostridium Difficile Infections among Adults and Children in Mwanza/Tanzania: is it an Underappreciated Pathogen among Immunocompromised Patients in sub-Saharan Africa? New microbes and new infections, 8. pp. 99-102. ISSN 2052-2975

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Abstract

Little is known regarding the epidemiology Clostridium difficile in developing countries. Fresh stool samples from patients with diarrhoea were cultured anaerobically. C. difficile was detected in nine (6.4%) of 141 (95% confidence interval 4.2-13.1), of which seven (77.8%) were from children. HIV infection, prolonged hospitalization and antibiotic use were independent factors associated with the occurrence of C. difficile in the gastrointestinal tract. Two of the toxigenic isolates were typed as ribotype 045, and the other two had unknown ribotype. All C. difficile isolates were susceptible to metronidazole, moxifloxacin and clarithromycin, while three isolates were resistant to clarithromycin. C. difficile may be an important pathogen causing diarrhoea in sub-Saharan Africa among immunocompromised patients.

Item Type: Article
Keywords: Clostridium difficile, Diarrhoea, Immunocompromised, sub-Saharan, Epidemiology, Clostridium fifficile, moxifloxacin, clarithromycin, Tanzania
Subjects: Emerging and Re-emerging Infectious Diseases
Divisions: Catholic University of Health and Allied Sciences (CUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 04 Feb 2016 07:31
Last Modified: 04 Feb 2016 07:31
URI: http://ihi.eprints.org/id/eprint/3591

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