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Malaria With Sickle Cell Disease : The Changing Scenario in Endemic Area

Patel, B. and Gandhi, D. J. (2016) Malaria With Sickle Cell Disease : The Changing Scenario in Endemic Area. Indian Journal of Research, 5 (4). ISSN 2250-1991

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Abstract

It was believed that current prevalence of MALARIA in many tropical populations reflects selection for the carrier form and sickle cell disease(SCD) through a survival advantage. 150 years after this hypothesis, the epidemiological description of relationships between SCD and malaria has changed specially in malaria endemic areas. In this study our aim was to study the occurance of malaria , its clinical features and complications in sickle cell disease. This was a retrospective analysis of the data collected from children age 1 to 18 years admitted to Dhiraj Hospital during January 2010 through December 2010. We studied the clinical features, complications, lab investigations of malarial infections in these children, stratified by SCD status. we had 44 patients with SCD who had p.vivax(26 i.e. 58%), and p.falciparum (18 i.e.42%) malaria proven by smear as well as RDT. In these patients 48%(22) had complicated malaria. 75%(34) had thrombocytopenia , 80% (36) had severe anemia (Hb<7gm/dl), all patients had bodyache and limb pain as chief complaints with high grade fever, 10%(i.e. 4) had acute chest pain and 20%(i.e. 8) had severe pain in abdomen, 2-2(5%) had acute renal failure, acute respiratory distress and convulsions as complications. Mean HbF concentration was 18.6 % . Although hemoglobin S is considered to be protective against Plasmodium , this is not always the case and in these children SCD complicated the diagnosis of malaria because hemolysis was related to the infection rather than to SCD.

Item Type: Article
Keywords: Malaria, Sickle cell disease
Subjects: Health Systems > Surveillance, monitoring & evaluation
Malaria > Surveillance, monitoring, evaluation
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 27 Jun 2016 05:41
Last Modified: 27 Jun 2016 05:41
URI: http://ihi.eprints.org/id/eprint/3768

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