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Sickle Cell Disease: New Opportunities and Challenges in Africa.

Makani, J., Ofori-Acquah, S. F., Nnodu, O., Wonkam, A. and Ohene-Frempong, K. (2013) Sickle Cell Disease: New Opportunities and Challenges in Africa. The Scientific World Journal, 2013. p. 193252. ISSN 1537-744X

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Sickle cell disease (SCD) is one of the most common genetic causes of illness and death in the world. This is a review of SCD in Africa, which bears the highest burden of disease. The first section provides an introduction to the molecular basis of SCD and the pathophysiological mechanism of selected clinical events. The second section discusses the epidemiology of the disease (prevalence, morbidity, and mortality), at global level and within Africa. The third section discusses the laboratory diagnosis and management of SCD, emphasizing strategies that been have proven to be effective in areas with limited resources. Throughout the review, specific activities that require evidence to guide healthcare in Africa, as well as strategic areas for further research, will be highlighted.

Item Type: Article
Keywords: Sickle Cell Disease, Sickle Haemoglobin, Africa
Subjects: Health Systems > Surveillance, monitoring & evaluation
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 27 Jun 2016 05:36
Last Modified: 27 Jun 2016 05:36

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