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Urban and Rural Prevalence of Diabetes and Pre-diabetes and Risk Factors Associated with Diabetes in Tanzania and Uganda.

Chiwanga, F. S., Njelekela, M. A., Diamond, M. B., Bajunirwe, F., Guwatudde, D., Nankya-Mutyoba, J., Kalyesubula, R., Adebamowo, C., Ajayi, I., Reid, T. G., Volmink, J., Laurence, C., Adami, H.-O., Holmes, M. D. and Dalal, S. (2016) Urban and Rural Prevalence of Diabetes and Pre-diabetes and Risk Factors Associated with Diabetes in Tanzania and Uganda. Global health action, 9. p. 31440. ISSN 1654-9880

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Abstract

The increase in prevalence of diabetes and pre-diabetes in sub-Saharan Africa underlines the importance of understanding its magnitude and causes in different population groups. We analyzed data from the Africa/Harvard Partnership for Cohort Research and Training (PaCT) studies to determine the prevalence of diabetes and pre-diabetes and risk factors associated with diabetes. Participants were randomly selected from peri-urban (n=297) and rural (n=200) communities in Uganda, and teachers were recruited from schools (n=229) in urban Tanzania. We used a standardized questionnaire to collect socio-demographic and self-reported disease status including diabetes status. Blood glucose was also measured after participants fasted for 8 h. We used standard protocols for anthropometric and blood pressure measurement. The overall prevalence of diabetes was 10.1% and was highest in rural Ugandan residents (16.1%) compared to teachers in Tanzania (8.3%) and peri-urban Ugandan residents (7.6%). The prevalence of pre-diabetes was 13.8%. The prevalence of self-reported diabetes was low across all sites, where 68% of participants with diabetes were not captured by self-report. In multivariable logistic regression analysis, family history (OR 2.5, 95% CI: 1.1, 5.6) and hypertension (OR 2.3, 95% CI: 1.1, 5.2) were significantly associated with diabetes. The prevalence of diabetes and pre-diabetes in Uganda and Tanzania is high, differs markedly between population groups, and remains undiagnosed in an alarmingly high proportion of individuals. These findings highlight the need for large-scale, prospective studies to accurately quantify the burden and identify effective intervention and treatment strategies across diverse African populations.

Item Type: Article
Keywords: Tanzania, Uganda, Non-communicable, Risk factors, sub-Saharan Africa, underdiagnoses
Subjects: Non-communicable disease (NCD) > Diabetes
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 26 Jun 2016 08:08
Last Modified: 26 Jun 2016 08:08
URI: http://ihi.eprints.org/id/eprint/3818

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