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Serological Evidence of Acute Rubella Infection among Under-Fives in Mwanza: A Threat to Increasing Rates of Congenital Rubella Syndrome in Tanzania.

Mirambo, M. M., Aboud, S., Mushi, M. F., Seugendo, M., Majigo, M., Groß, U. and Mshana, S. E. (2016) Serological Evidence of Acute Rubella Infection among Under-Fives in Mwanza: A Threat to Increasing Rates of Congenital Rubella Syndrome in Tanzania. Italian journal of pediatrics, 42 (1). p. 54. ISSN 1824-7288

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Abstract

Control of rubella infection is essential for preventing congenital rubella syndrome (CRS) and one of the important steps is to define a target population for vaccination. Therefore this study was done to determine serological evidence of acute rubella infection among under-fives in order to anticipate the magnitude of rubella virus transmission in Tanzania. A cross-sectional study involving children aged between 1 and 59 months was conducted between September and October 2014 before national rubella vaccination campaigns commenced. Rubella IgM antibodies were detected using commercial indirect enzyme-linked immunosorbent assay (ELISA). Data were analyzed using STATA version 11. A total of230 under-fives were enrolled, their median age was 14 (Interquartile range (IQR) 7-26) months. The overall seroprevalence of rubella IgM antibodies was 10.9 % (25/230) with two confirmed cases of CRS. Two-sample Wilcoxon rank-sum test showed that the median age of rubella IgM seropositive children was significantly higher than that of IgM seronegative children (39 IQR: 18-51months vs. 14 IQR: 7-24 months, P < 0.001). On multivariate logistic regression analysis increase in age (OR: 1.07, 95 % CI; 1.03-1.1, P < 0.001) and residing in rural areas (OR: 8.07, 95 % CI; 1.43-45.6, P = 0.018) were independently found to predict acute rubella infection among under-fives. Our findings indicate that rubella virus is prevalent in our setting posing a risk of transmitting to childbearing aged women hence increasing the risk of CRS. Increasing prevalence of acute infection with age in under-fives indicates the protective role of maternal antibodies among infants. The sustained vaccination programme of under-fives as effective measure to control CRS should be emphasized in developing countries.

Item Type: Article
Keywords: Rubella, IgM, Under-fives, Mwanza, Tanzania, Congenital rubella syndrome
Subjects: Emerging and Re-emerging Infectious Diseases
Divisions: Catholic University of Health and Allied Sciences (CUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 26 Jun 2016 08:08
Last Modified: 26 Jun 2016 08:08
URI: http://ihi.eprints.org/id/eprint/3826

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