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Absence of Hepatitis Delta Infection in a Large Rural HIV Cohort in Tanzania.

Winter, A., Letang, E., Vedastus Kalinjuma, A., Kimera, N., Ntamatungiro, A., Glass, T., Moradpour, D., Sahli, R., Le Gal, F., Furrer, H. and Wandeler, G. (2016) Absence of Hepatitis Delta Infection in a Large Rural HIV Cohort in Tanzania. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 46. pp. 8-10. ISSN 1878-3511

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Abstract

The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania. All HBV-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and -positive patients. Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/μl. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them. No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.

Item Type: Article
Keywords: False-positive serology, HIV, Hepatitis delta, Sub-Saharan Africa, Tanzania
Subjects: Equity, gender, social determinants
Emerging and Re-emerging Infectious Diseases
Divisions: Ifakara Health Institute > Interventions
Depositing User: Mr Joseph Madata
Date Deposited: 26 Jun 2016 08:06
Last Modified: 26 Jun 2016 08:06
URI: http://ihi.eprints.org/id/eprint/3829

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