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High Oral Carriage of Non-albicans Candida spp. among HIV-Infected Individuals.

Mushi, M. F., Mtemisika, C. I., Bader, O., Bii, C., Mirambo, M. M., Groß, U. and Mshana, S. E. (2016) High Oral Carriage of Non-albicans Candida spp. among HIV-Infected Individuals. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 49. pp. 185-8. ISSN 1878-3511

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Abstract

Non-albicans Candida (NAC) spp. in immunocompromised patients are linked to invasive infections with narrow treatment choice. This study aimed at comparing the oral colonization of NAC spp. between HIV and non-HIV infected individuals in Mwanza, Tanzania. Oral rinse of 351 HIV-infected and 639 non-HIV infected individuals were collected between March and July 2015. Phenotypic identifications of Candida spp. was done using Candida Chromogenic agar and confirmed by MALDI-TOF MS. NAC spp. were detected in 36/351 (10.3%) HIV-infected individuals compared to 28/639 (4.4%) of non-HIV infected individuals; P=0.0003. In HIV infected individuals, commonly isolated NAC spp. were Candida tropicalis, 10(2.8%), C. krusei (Issatschenki orientalis) 9(2.6%) and C. glabrata 8(2.3%). While for non-HIV infected individuals C. dubliniensis 8(1.3%) and C. tropicalis 5(0.9%) were commonly detected. As CD4 count/μl decreases by one unit the risk of being colonized by NAC spp. among HIV infected individuals increases by 1% (OR 1.01, 95% CI; 1.001-1.004, P=0.001).B The prevalence of NAC spp. is high among HIV-infected individuals with low CD4 count placing them at higher risk of invasive infections. Further studies to investigate the role of NAC spp. in causing invasive infections among immunocompromised patients are recommended.

Item Type: Article
Keywords: HIV, Oral health, non-Candida albicans Candida spp.
Subjects: Emerging and Re-emerging Infectious Diseases
HIV > Surveillance
Divisions: Catholic University of Health and Allied Sciences (CUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 09 Sep 2016 03:27
Last Modified: 09 Sep 2016 03:27
URI: http://ihi.eprints.org/id/eprint/3919

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