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Tuberculosis among HIV-infected population: incidence and risk factors in rural Tanzania.

Said, K., Verver, S., Kalingonji, A., Lwilla, F., Mkopi, A., Charalambous, S. and Reither, K. (2017) Tuberculosis among HIV-infected population: incidence and risk factors in rural Tanzania. African health sciences, 17 (1). pp. 208-215. ISSN 1729-0503

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Abstract

The incidence of tuberculosis among HIV-infected populations with high CD4 count in high burden countries has not been well studied. To assess the TB incidence in HIV-infected adults and its associated risk factors. A cohort study with retrospective review of medical records and prospective follow-up of HIV-infected adult participants attending CTC who were 18-55 years old, had CD4 count more than 250 cells/mm(3) in the period of 2008-2010 and were not on ART at enrolment. Cox proportional hazard regression was used to explore the predictors of incident TB. Overall 777 (24%) of 3,279 CTC enrolled HIV-infected adults fulfilled the inclusion criteria of the study. The incidence of TB in the study population ranged from 0.8/100 per person years (PY) at risk (95% CI 0.5-1.3) in the main analysis to 1.7/100 PY at risk (95% CI 1.0-2.6) in sensitivity analyses. Only prior history of TB disease was found to have a significant association with an increased risk of TB, hazard ratio 5.7 (95% CI 2.0-16.4, p value 0.001). Tuberculosis incidence among HIV-infected adults with medium/high CD4 count in Bagamoyo is lower than in other high TB burden countries. Previously TB treated patients have a much higher risk of getting TB again than those who never had TB before.

Item Type: Article
Keywords: Tuberculosis, HIV, Care and Treatment Center, CD4 cell count
Subjects: HIV > Treatment
Divisions: Ifakara Health Institute > Interventions
Depositing User: Mr Joseph Madata
Date Deposited: 29 Oct 2017 19:11
Last Modified: 29 Oct 2017 19:11
URI: http://ihi.eprints.org/id/eprint/4266

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