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Performance of The Xpert® MTB/RIF Assay in an Active Case-Finding Strategy: A Pilot Study From Tanzania

Ntinginya, E.N., Squire, S.B., Millington, K.A., Mtafya, B., Saathoff, E., Heinrich, N., Rojas-Ponce, G., Kowuor, D., Maboko, L., Reither, K., Clowes, P., Hoelscher, M. and Rachow, A. (2012) Performance of The Xpert® MTB/RIF Assay in an Active Case-Finding Strategy: A Pilot Study From Tanzania. The International Journal of Tuberculosis and Lung Disease. pp. 1-3. (Submitted)

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Abstract

In this pilot study, we evaluated the Xpert® MTB/RIF assay in an active case-finding strategy, using two spot sputum samples collected within a 1-hour interval from household contacts of smear-positive TB index cases. Tuberculosis (TB) confirmed by culture served as the reference standard. Among 219 enrolled contacts, the yield of active TB was 2.3%. While the sensitivity of smear microscopy was 60% (95%CI 14.7–94.7), Xpert MTB/RIF achieved a sensitivity of 100% (95%CI 47.81–100.0). All culture-confirmed cases tested positive by Xpert MTB/RIF on the first submitted sample, suggesting that the evaluation of only one sample could be sufficient for TB diagnosis in this context.

Item Type: Article
Keywords: Tuberculosis,Spot Sputum,Xpert MTB/RIF,Samples; Index Cases
Subjects: Tuberculosis > Diagnosis
Divisions: Other
Depositing User: Mr Joseph Madata
Date Deposited: 17 Sep 2012 07:07
Last Modified: 17 Sep 2012 07:07
URI: http://ihi.eprints.org/id/eprint/580

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