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Screening of Traditionally Used Plants for in Vivo Antimalarial Activity in Mice.

Innocent, E., Moshi, M. J., Masimba, P. J., Mbwambo, Z. H., Kapingu, M. C. and Kamuhabwa, A. (2009) Screening of Traditionally Used Plants for in Vivo Antimalarial Activity in Mice. African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines, 6 (2). pp. 163-167. ISSN 0189-6016

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Aqueous ethanol (80%) extracts of six plants used traditionally for treatment of malaria, Vepris glomerata (F.Hoffm.) Engl (Rutaceae), Maranthus floribunda (Bak.) F.White (Chrysobalanaceae), Strophanthus eminii Asch. & Pax ex Pax (Apocynaceae), Cassia abbreviata Oliv. (Leguminosae) and Caesalpinia bonducella L. Fleming (Fabaceae) were screened for antimalarial activity to establish validity of their claims. The extracts exhibited antimalarial activity in the 4-day Peter's suppressive antimalarial assay in mice inoculated with red blood cells parasitized with Plasmodium berghei. The extracts gave ID(50) values of 42.8, 111.0, 639.3 and 1560 mg/kg body wt for C. bonducella, C. abbreviata, T. furialis and S. eminii, respectively. The ID(50) values for V. glomerata and M. floribunda were above 2400 mg/kg body wt, above which point solubility was a problem. All the tested extracts were innocuous to the mice, up to 2400 mg/kg body wt, suggesting they may be safe for short-term use.

Item Type: Article
Keywords: Antimalarial activity, Plasmodium berghei, traditional medicines
Subjects: Malaria > Surveillance, monitoring, evaluation
Malaria > Diagnosis & treatment
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 17 Dec 2012 10:14
Last Modified: 17 Dec 2012 10:14

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