ehealth digital library

Digital library of
the Tanzania
health
community

Species Distribution and in Vitro Antifungal Susceptibility of Oral Yeast Isolates from Tanzanian HIV-Infected Patients With Primary and Recurrent Oropharyngeal Candidiasis.

Hamza, O. J. M., Matee, M. I. N., Moshi, M. J., Simon, E. N. M., Mugusi, F., Mikx, F. H. M., Helderman, W. H. v. P., Rijs, A. J. M. M., van der Ven, A. J. A. M. and Verweij, P. E. (2008) Species Distribution and in Vitro Antifungal Susceptibility of Oral Yeast Isolates from Tanzanian HIV-Infected Patients With Primary and Recurrent Oropharyngeal Candidiasis. BMC microbiology, 8. p. 135. ISSN 1471-2180

[img]
Preview
PDF
muhas.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (281kB)

Abstract

In Tanzania, little is known on the species distribution and antifungal susceptibility profiles of yeast isolates from HIV-infected patients with primary and recurrent oropharyngeal candidiasis. A total of 296 clinical oral yeasts were isolated from 292 HIV-infected patients with oropharyngeal candidiasis at the Muhimbili National Hospital, Dar es Salaam, Tanzania. Identification of the yeasts was performed using standard phenotypic methods. Antifungal susceptibility to fluconazole, itraconazole, miconazole, clotrimazole, amphotericin B and nystatin was assessed using a broth microdilution format according to the guidelines of the Clinical and Laboratory Standard Institute (CLSI; M27-A2). Candida albicans was the most frequently isolated species from 250 (84.5%) patients followed by C. glabrata from 20 (6.8%) patients, and C. krusei from 10 (3.4%) patients. There was no observed significant difference in species distribution between patients with primary and recurrent oropharyngeal candidiasis, but isolates cultured from patients previously treated were significantly less susceptible to the azole compounds compared to those cultured from antifungal naïve patients. C. albicans was the most frequently isolated species from patients with oropharyngeal candidiasis. Oral yeast isolates from Tanzania had high level susceptibility to the antifungal agents tested. Recurrent oropharyngeal candidiasis and previous antifungal therapy significantly correlated with reduced susceptibility to azoles antifungal agents.

Item Type: Article
Keywords: In Vitro Antifungal Susceptibility;HIV-Infected Patients;Oropharyngeal Candidiasis;Oral Yeast Isolates;Tanzania
Subjects: HIV > Surveillance
Divisions: Muhimbili University of Health and Allied Sciences (MUHAS)
Depositing User: Mr Joseph Madata
Date Deposited: 08 Jan 2013 06:40
Last Modified: 08 Jan 2013 06:40
URI: http://ihi.eprints.org/id/eprint/998

Actions (login required)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics